Hydrocodone and chlorpheniramine combination is used to relieve cough and nasal congestion associated with the common cold and upper respiratory allergies in adults. Each 5 mL of TUSSIONEX Pennkinetic Extended-Release Suspension contains hydrocodone polistirex equivalent to 10 mg of hydrocodone bitartrate and chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate. Using chlorpheniramine and hydrocodone with other drugs that slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Find patient medical information for Chlorpheniramine-Hydrocodone ER Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Misuse or abuse of this medicine (hydrocodone and chlorpheniramine extended-release capsules) can lead to overdose and death. If you have questions, talk with your doctor. If you have questions, talk with your doctor. Uses. This combination product is used to treat coughs and other symptoms caused by the common cold or allergies. This product contains 2 medications: hydrocodone and chlorpheniramine. An overdose on hydrocodone can be fatal. So take Tussionex only as directed by your healthcare provider, and make sure he or she knows about any other medicines or supplements you're taking. So take Tussionex only as directed by your healthcare provider, and make sure he or she knows about any other medicines or supplements you're taking. Each 5 mL of TUSSIONEX Pennkinetic Extended-Release Suspension contains hydrocodone polistirex equivalent to 10 mg hydrocodone bitartrate, and chlorpheniramine polistirex equivalent to 8 mg chlorpheniramine maleate. Shake well before using. Rinse the measuring device with water after each use. What is chlorpheniramine and hydrocodone (S-T Forte 2, TussiCaps, Tussionex PennKinetic)? Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing , itching, watery eyes, and runny nose. Chlorpheniramine and hydrocodone (Tussionex) is a drug prescribed for the treatment of cough and congestion associated with allergies, colds, and other lung infections. Side effects, drug interactions, dosage, warnings and precautions, and pregnancy information should be reviewed prior to taking any medication.